• pharmaceutical chemistry
• Organic chemistry
• Medicinal chemistry
• Drug design
• Biochemistry
• General Chemistry
• Physical Pharmacy
• Research graduate project

• Drug Bioconjugation, Drug delivery systems

• Hamdi Nsairat, Ali Al-Samydai, Mohamed El-Tanani, Ashok K Shakya, Somaya Ahmad, Shorouq Alsotari, Walhan Alshaer, Ammar Shanneir, Munib M Saket, Tawfiq A Arafat (2024) In vitro dissolution equivalence of Jordanian sildenafil generics via validated, stability-indicating HPLC method Bioanalysis, 2
• Rohimah Mohamud Mohammad A.I. Al-Hatamleh, Walhan Alshaer, Ma’mon M. Hatmal, Abed Alqader Ibrahim, Anthony L. Dellinger, Hamdi Nsairat, Maram Abdaljaleel, Mohd Zulkifli Mustafa (2024) Synthesis, characterization, and wound healing activity of alginate-based polymeric nanoparticles loaded with stingless bee honey Biocatalysis and Agricultural Biotechnology, 103329
• Walhan Alshaer Haya Faddah, Hamdi Nsairat, Naeem M. Shalan, Mohamed El-Tanani, Dana A. Alqudah (2024) Preparation, Optimization and In vitro Evaluation of Doxorubicin‐loaded into Hyaluronic Acid Coated Niosomes Against Breast Cancer Chemistry & Biodiversity, 1
• Walhan Alshaer Zahraa M. Al Zubaidi, Hamdi Nsairat, Naeem M. Shalan, Leena Al-Asfoor, Dana A. Alqudah, Mairvat Mrahleh (2024) Hyaluronic Acid – Coated Niosomes for Curcumin Targeted Delivery into Breast Cancer Cells ChemistrySelect, 9(3)
• Mohamed El-Tanani, Syed Arman Rabbani, Areeg Anwer Ali, Ibrahim Ghaleb Ali Alfaouri, Hamdi Al Nsairat, Israa Hamid Al-Ani, Alaa A Aljabali, Manfredi Rizzo, Dimitrios Patoulias, Mohammad Ahmed Khan, Suhel Parvez, Yahia El-Tanani (2024) Circadian rhythms and cancer: implications for timing in therapy Discover Oncology, 15/1/767
• M Amin Tamma, Hamdi Nsairat, Mohamed El-Tanani, Razan Madi (2024) In vitro evaluation of lipidic nanocarriers for mebendazole delivery to improve anticancer activity Drug Development and Industrial Pharmacy, 5-11-917-926
• Abed Alqader Ibrahim, Hamdi Nsairat, Mazen Al-Sulaibi, Mohamed El-Tanani, Areej M Jaber, Zainab Lafi, Rahmeh Barakat, Duaa Azmi Abuarqoub, Ismail Sami Mahmoud, Sherine O Obare, Alaa AA Aljabali, Alaaldin M Alkilany, Walhan Alshaer (2024) Doxorubicin conjugates: a practical approach for its cardiotoxicity alleviation Expert Opinion on Drug Delivery, 21(3)
• Mohamed El-Tanani, Hamdi Nsairat, Alaa A Aljabali, Ismail I Matalka, Alaaldin M Alkilany, Murtaza M Tambuwala (2024) Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer Expert Opinion on Drug Delivery, 21(2)
• Ruqaya Alhaddad, Bassam M Abualsoud, Ibrahim Al-Deeb, Hamdi Nsairat (2024) Green synthesized Zingiber officinale-ZnO nanoparticles: anticancer efficacy against 3D breast cancer model Future Science OA, 10/1/2419806
• Hamdi Nsairat, Areej M Jaber, Haya Faddah, Somaya Ahmad (2024) Oleuropein impact on colorectal cancer Future Science OA, 1
• Dalya Saidi, Marya Obeidat, Shrouq Alsotari, Abed-Alqader Ibrahim, Rula Al-Buqain, Suha Wehaibi, Dana A Alqudah, Hamdi Nsairat, Walhan Alshaer, Alaaldin M Alkilany (2024) Formulation optimization of lyophilized aptamer-gold nanoparticles: Maintained colloidal stability and cellular uptake Heliyon, 10(10)
• Balqis Abu-Hdaib, Hamdi Nsairat, Mohamed El-Tanani, Ibrahim Al-Deeb, Nabil Hasasna (2024) In vivo evaluation of mebendazole and Ran GTPase inhibition in breast cancer model system Nanomedicine, 1(15)
• Asma Ghazzy, Hamdi Nsairat, Rana Said, Obada A Sibai, Aseel AbuRuman, Alaa S Shraim (2024) Magnetic iron oxide-based nanozymes: from synthesis to application Nanoscale Advances, 1
• Ali Al-Samydai, Hamdi Nsairat, Maha N Abu Hajleh, Bayan Aburas, Amal Akour, Tha’er Husam Ata, Tabarek H Mahmood, Tabarak Riyadh Al-sammarraie, Rawan Atta, Rahaf Ali, Qasim Khalid Alazzawi, Ahmed Aburjai, Simone Carradori (2024) Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy Natural Product Research, 1(20)
• Mohamed El-Tanani, Hamdi Nsairat, Ismail I Matalka, Yin Fai Lee, Manfredi Rizzo, Alaa A Aljabali, Vijay Mishra, Yachana Mishra, Altijana Hromić-Jahjefendić, Murtaza M Tambuwala (2024) The impact of the BCR-ABL oncogene in the pathology and treatment of chronic myeloid leukemia Pathology-Research and Practice, 155161
• Ali Al-Samydai, Maha N Abu Hajleh, Farah Al-Sahlawi, Hamdi Nsairat, Arwa Al Khatib, Moath Alqaraleh, Alia K Ibrahim (2024) Advancements of metallic nanoparticles: A promising frontier in cancer treatment Science Progress, 107/4/00368504241274967
• Wafa’A AL-Haj, Hamdi Nsairat, Mohamed El-Tanani (2024) Pimozide-loaded nanostructured lipid carriers: Repurposing strategy against lung cancer Science Progress, 107/4/00368504241296304
• Bassam M Abualsoud & Hamdi Nsairat Hasan Al-Nasrawi, Naeem Shalan (2024) Preparation, characterization and in vitro evaluation of 5-fluorouracil loaded into chitosan–acacia gum nanoparticles THERAPEUTIC DELIVERY, 136
• Nisreen Asha & Walhan Alshaer Zainab Lafi , Lobna Gharaibeh, Hamdi Nsairat (2023) Aptasensors: employing molecular probes for precise medical diagnostics and drug monitoring BIOANALYSIS, 141
• Alaa Al-Sanabrah & Mohamed El-Tanani Hamdi Nsairat , Walhan Alshaer , Zainab Lafi , Somaya Ahmad (2023) Development and validation of reversed-phase-HPLC method for simultaneous quantification of fulvestrant and disulfiram in liposomes BIOANALYSIS, 137
• Tabarek H Mahmood, Ali Al‐Samydai, Mazen Al Sulaibi, Moath Alqaraleh, Anas Ibrahim Abed, Naeem Shalan, Alaa Alsanabrah, Shrouq Taiseer Alsotari, Hamdi Nsairat, Walhan Alshaer (2023) Development of pegylated nano‐phytosome formulation with oleuropein and rutin to compare anti‐colonic cancer activity with Olea europaea leaves extract Chemistry & Biodiversity, 20(8)
• Noorin Manhal Al‐Ekaid, Ali Al‐Samydai, Ibrahim Al‐deeb, Hamdi Nsairat, Khaled Khleifat, Walhan Alshaer (2023) Preparation, characterization, and anticancer activity of pegylated nano liposomal loaded with rutin against human carcinoma cells (HT‐29) Chemistry & Biodiversity, 20(11)
• Tabarek H. Mahmood, Ali Al-Samydai, Mazen Al Sulaibi, Moath Alqaraleh, Anas Ibrahim Abed, Naeem Shalan, Alaa Alsanabrah, Shrouq Taiseer Alsotari, Hamdi Nsairat, Walhan Alshaer (2023) Development of Pegylated Nano-Phytosome Formulation with Oleuropein and Rutin to Compare Anti-Colonic Cancer Activity with Olea Europaea Leaves Extract Chemistry and Biodiversity, Volume20, Issue8 August 2023 e202300534
• Said I. Ismail Walhan Alhaer Ezaldeen Esawi, Hamdi Nsairat, Ismail Sami Mahmoud, Zainab Lafi, Abdulfattah Al-Kadash, Bayan Abu Al-Ragheb (2023) Clinical use and future perspective of aptamers Elsevier, 2023, Pages 481-520
• Hamdi Nsairat 1, Dima Khater 2, Fadwa Odeh 3, Areej M. Jaber 1, Mazen A.M. Al Sulaibi 1, Walhan Alshaer 4, Abeer Al Bawab 3 5, Mohammad S. Mubarak (2023) Phytosomes: a modernistic approach to the delivery of herbal drugs Elsiver, 2023, Pages 301-355
• Hamdi Nsairat a, Zainab Lafi a, Mazen Al-Sulaibi a, Lobna Gharaibeh a, Walhan Alshaer (2023) Impact of nanotechnology on the oral delivery of phyto-bioactive compounds Food Chemistry, Volume 424, 30 October 2023, 136438
• Ali Al-Samydai Moath Al Qaraleh Khaldun M. Al Azzam Amal Mayyas Hamdi Nsairat Maha N. Abu Hajleh Lidia K. Al-Halaseh Nehaya Al-Karablieh Amal Akour Fatima Alshaik Walhan Alshaer (2023) Formulating co-loaded nanoliposomes with gallic acid and quercetin for enhanced cancer therapy Heliyon, VOLUME 9, ISSUE 6, E17267, JUNE 2023
• Mohamed El-Tanani ,Hamdi Nsairat ,Vijay Mishra,Alaa A. A. Aljabali ,Ángel Serrano-Aroca and Murtaza M. Tambuwala (2023) Ran GTPase and Its Importance in Cellular Signaling and Malignant Phenotype International Journal of Molecular Sciences, 2023, 24(4), 3065
• Maram Kutkut, Ashok K. Shakya , Hamdi Nsairat1 , Mohamed El-Tanani (2023) Formulation, development, and in vitro evaluation of a nanoliposomal delivery system for mebendazole and gefitinib Journal of Applied Pharmaceutical Science, 13,001-014
• Fedaa Adaileh a, Walhan Alshaer b, Hamdi Nsairat c, Dana A. Alqudah b, Suha Wehaibi b, Fadwa Daoud b, Rula Al-Buqain b d, Shrouq Alsotari b, Abeer Al Bawab a, Fadwa Odeh a (2023) Curcumin-loaded γ -cyclodextrin-grafted hyaluronic acid nanoassimblies: In vitro investigation of anti-proliferative, wound healing, and anti-inflammatory potential Journal of Drug Delivery Science and Technology, Volume 87, September 2023, 104886
• Hamdi Nsairat a, Mazen Al-Sulaibi a, Walhan Alshaer (2023) PEGylated nanoassemblies composed of edelfosine and fulvestrant drugs: In vitro antiproliferative effect against breast cancer cells Journal of Drug Delivery Science and Technology, Volume 85, August 2023, 104612
• Hamdi Nsairat,Abed Alqader Ibrahim,Areej M. Jaber,Sharif Abdelghany,Randa Atwan,Naeem Shalan,Hiba Abdelnabi,Fadwa Odeh,Mohamed El-Tanani &Walhan Alshaer show less (2023) Liposome bilayer stability: emphasis on cholesterol and its alternatives Journal of Liposome Research, 1-25
• Mohamed El-Tanani a b, Angela Platt-Higgins c, Hamdi Nsairat a, Ismail I. Matalka d e, Khaled Abdul-Aziz Ahmed a, Shu-Dong Zhang f, Walhan Alshaer g, Abdalla Awidi g, Kyle B. Matchett h, Alaa A. Aljabali i, Vijay Mishra j, Ángel Serrano-Aroca k, Murtaza M. Tambuwala l, Philip S. Rudland (2023) Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer Life Sciences, Volume 329, 15 September 2023, 121964
• Mohamed El-Tanani a b, Hamdi Nsairat a, Alaa A. Aljabali c, Ángel Serrano-Aroca d, Vijay Mishra e, Yachana Mishra f, Gowhar A. Naikoo g, Walhan Alshaer h, Murtaza M. Tambuwala (2023) Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis Life Sciences, Volume 323, 15 June 2023, 121662
• Mohamed El-Tanani, Hamdi Nsairat, Ismail I. Matalka, Alaa A. A. Aljabali, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Sai Raghuveer Chava, Nitin B. Charbe & Murtaza M. Tambuwala (2023) Impact of exosome therapy on pancreatic cancer and its progression Medical Oncology, 40, Article number: 225 (2023)
• Hamdi Nsairat , Walhan Alshaer , Fadwa Odeh , Ezzaldeen Esawi , Dima Khater d, Abeer Al Bawab , Mohamed El-Tanani , Abdalla Awidi , Mohammad S. Mubarak (2023) Recent advances in using liposomes for delivery of nucleic acid-based therapeutics OpenNano, Volume 11, May 2023, 100132
• by Ashok K. Shakya 1,2,*ORCID,Mazen Al-Sulaibi 1,2,Rajashri R. Naik 2,3,Hamdi Nsairat 1,2,Sara Suboh 1 andAbdelrahman Abulaila 1 (2023) Review on PLGA Polymer Based Nanoparticles with Antimicrobial Properties and Their Application in Various Medical Conditions or Infections Polymers, Volume 15 Issue 17 10.3390/polym15173597
• Sara Suboh andAbdelrahman Abulaila Ashok K. Shakya,Mazen Al-Sulaibi ,Rajashri R. Naik ,Hamdi Nsairat (2023) Review on PLGA Polymer Based Nanoparticles with Antimicrobial Properties and Their Application in Various Medical Conditions or Infections Polymers, 15(14)
• Hamdi Nsairat , Dima Khater , Usama Sayed , Fadwa Odeh , Abeer Al Bawab , Walhan Alshaer (2022) Liposomes: structure, composition, types, and clinical applications Heliyon, e09394
• Walhan Alshaer ,Hamdi Nsairat ,Zainab Lafi ,Omar M. Hourani ,Abdulfattah Al-Kadash ,Ezaldeen Esawi and Alaaldin M. Alkilany (2022) Quality by Design Approach in Liposomal Formulations: Robust Product Development Molecules, 2023, 28(1), 10
• Fedaa Adaileh ,Walhan Alshaer ,Hamdi Nsairat ,Dana A. Alqudah ,Areej M. Jaber and Abeer Al Bawab (2022) Synthesis of Mono-Amino Substituted γ-CD: Host–Guest Complexation and In Vitro Cytotoxicity Investigation Molecules, 2022, 27(5), 1683
• Mohammad A. Obeid ,Hamid A. Bakshi ,Walhan Alshaer Raed M. Ennab ,Bahaa Al-Trad ,Wesam Al Khateeb ,Khalid M. Al-Batayneh ,Abdulfattah Al-Kadash,Shrouq Alsotari ,Hamdi Nsairat and Murtaza M. Tambuwala (2022) Synthesis, Characterization, and Assessment of Anti-Cancer Potential of ZnO Nanoparticles in an In Vitro Model of Breast Cancer Molecules, 2022, 27(6), 1827
• Hamdi Nsairat, Ismail S. Mahmoud, Fadwa Odeh, Duaa Abuarqoub, Hafsa Al-Azzawi Rand Zaza, Malak I. Qadri, Said Ismail, Abeer Al Bawab, Abdalla Awidi and Walhan Alshaer (2022) Grafting of Anti-nucleolin Aptamer into Preformed and Remotely Loaded Liposomes Through Aptamer-Cholesterol Post-insertion RSC advance, 10, 36219-36229
• Hamdi Nsairat, Walhan Alshaer, Abdulfattah Al-Kadash, Wissam Helal, Lubna Alrawashdeh, Anthony Day, Khaleel I. Assaf, Rola Hassouneha, Fadwa Odeh and Abeer Al Bawab (2022) Cinnamaldehyde–cucurbituril complex: investigation of loading efficiency and its role in enhancing cinnamaldehyde in vitro anti-tumor activity RSC Advanves, 12, 7540-7549
• Ismail Sami Mahmoud*, Ma’mon M. Hatmal, Duaa Abuarqoub, Ezaldeen Esawi, Hiba Zalloum, Suha Wehaibi, Hamdi Nsairat, and Walhan Alshaer* (2021) 1,4-Naphthoquinone Is a Potent Inhibitor of IRAK1 Kinases and the Production of Inflammatory Cytokines in THP-1 Differentiated Macrophages ACS OMEGA, https://doi.org/10.1021/acsomega.1c03081
• Dima Khater ,Hamdi Nsairat ,Fadwa Odeh ,Mais Saleh ,Areej Jaber 2,Walhan Alshaer ,Abeer Al Bawab and Mohammad S. Mubarak (2021) Design, preparation, and characterization of effective dermal and transdermal lipid nanoparticles: A review Cosmetics, 8(2), 39
• Hamdi Nsairat Dima Khater Fadwa Odeh Fedaa Al-Adaileh Suma Al-Taher Areej M. Jaber Walhan Alshaer Abeer Al Bawab Mohammad S.Mubarak (2021) Lipid nanostructures for targeting brain cancer Heliyon, Volume 7, Issue 9, September 2021, e07994
• Hamdi Nsairat, Areej Jaber and Mazen Alsulaibi (2021) Biosensors for Fungal Detection Journal of Pure and Applied Microbiology, 15(4):1719-1726
• Zainab Lafia, Walhan Alshaer, Ma'mon M. Hatmal, Malek Zihlif, Dana A. Alqudah, Hamdi Nsairat, Hanan Azzam, Talal Aburjai, Yasser Bustanji and Abdalla Awidi (2021) Aptamer-functionalized pH-sensitive liposomes for a selective delivery of echinomycin into cancer cells RSC Advanves, 11, 29164-29177
• Odeh, F., Nsairat, H., Alshaer, W., Alsotari, S., Buqaien, R., Ismail, S., Awidi, A. and Al Bawab, A. (2020) Remote loading of curcumin-in-modified β-cyclodextrins into liposomes using a transmembrane pH gradient RSC Advances, 9, 37148-37161
• (2019) Best scientific Poster 16th Jordanian conference of chemistry,
• . Odeh, F., Nsairat, H., Alshaer, W., Ismail, M. A., Esawi, E., Qaqish, B., Bawab, A. A. and Ismail, S. I. (2019) Aptamers Chemistry: Chemical Modifications and Conjugation Strategies Molecules, 25., Molecules, 25.
• Alshaer, W., Zraikat, M., Amer, A., Nsairat, H., Lafi, Z., Alqudah, D. A., Al Qadi, E., Alsheleh, T., Odeh, F., Alkaraki, A., Zihlif, M., Bustanji, Y., Fattal, E. and Awidi, A. (2019) Encapsulation of echinomycin in cyclodextrin inclusion complexes into liposomes: in vitro anti-proliferative and anti-invasive activity in glioblastoma RSC Advances, 9, 30976-30988
• Khalid, K, Nsairat, H , Zhang. J, (2016) The Presence of Interleukin 18 Binding Protein Isoforms in Chinese Patients with Rheumatoid Arthritis AMIS Medical Science , Volume 3, Issue 1, 103-113.
• Waled Amen Mohammed Ahmed, , Sawsan Mustafa Abdalla , Elsadig Yousif Mohamed , Osman Babiker Osman , Hamdi Nouri Najeeb Alnsairat (2015) Home Accidents Rate Among Under-Five Children and Predisposing Factors in Khartoum International Journal of Preventive Medicine Research, Vol. 1, No. 5, 2015, pp. 267-269

Published Books:

• Chapter 12 - Phytosomes: a modernistic approach to the delivery of herbal drugs (2023) Advanced and Modern Approaches for Drug Delivery Elsevier
• (2022) Aptamers in Theranostic Bionanomaterials Bentham
• Aptamers in Theranostic Bionanomaterials (2022) Bionanotechnology: Next-Generation Therapeutic Tool Bentham Science Publishers
• Clinical use and future perspective of aptamers (2022) Aptamers Engineered Nanocarriers for Cancer Therapy Elsevier