• Medicinal Chemistry
• drug desin
• Dosage Form Design

• Use computational tools to discover and design novel active molecules from synthetic and natural origin to treat diabetes.

• Belal O Al-Najjar, Manal A Abbas, Obada A Sibai, Fadi G Saqallah, Aya Y Al-Kabariti (2023) QSAR, structure-based pharmacophore modelling and biological evaluation of novel platelet ADP receptor (P2Y 12) antagonist RSC Medicinal Chemistry, 14
• Menier Al-Anazi, Melati Khairuddean, Belal O Al-Najjar, Mohammad Murwih Alidmat, Nik Nur Syazni Nik Mohamed Kamal, Musthahimah Muhamad (2022) Synthesis, anticancer activity and docking studies of pyrazoline and pyrimidine derivatives as potential epidermal growth factor receptor (EGFR) inhibitors Arabian Journal of Chemistry, 7,15,103864
• Mohamed El-Tanani, Arwa Omar Al Khatib, Belal O Al-Najjar, Ashok K Shakya, Yahia El-Tanani, Yin-Fai Lee, Ángel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Alaa A Aljabali, Rohit Goyal, Poonam Negi, Marzieh Ramezani Farani, Maryam Moradi Binabaj, Amir Gholami, Nitin B Charbe, Murtaza M Tambuwala (2022) Cellular and molecular basis of therapeutic approaches to breast cancer Cellular signalling, 110492
• Belal O Al-Najjar, Fadi G Saqallah, Manal A Abbas, Serena Z Al-Hijazeen, Obada A Sibai (2022) P2Y12 antagonists: Approved drugs, potential naturally isolated and synthesised compounds, and related in-silico studies European Journal of Medicinal Chemistry, 227,113924
• Fadi G Saqallah, Abdulsalam Q Almashhadani, Belal O Al-Najjar, Habibah A Wahab (2022) Delavirdine and Dolutegravir as Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro): An In-Silico Study Jordan Journal of Biological Sciences, 15,5
• Sahar Jaffal, Sawsan Oran, Mohammad Alsalem, Belal Al-Najjar (2022) Effect of Arbutus andrachne L. methanolic leaf extract on TRPV1 function: Experimental and molecular docking studies Journal of Applied Pharmaceutical Science, 12,10069-077
• Haitham H Al-Sa’doni, Hamdoon A Mohammed, Belal O Al-Najjar, Hossam H Al-Suod, H Ala’a, Y Esra’a, Alhelal Kafa’AS, Yaseen A Al-Soud (2021) Synthesis, Molecular Docking and Evaluation of Hetaryl Fragment Tagged 1H-1, 2, 4-Triazole Derivatives As Nematicidal Agents Jordan Journal of Chemistry (JJC), 16,1,1-11
• Menier Al-Anazi, Melati Khairuddean, Belal O Al-Najjar, Mohammad Murwih Alidmat, NNSNM Kamal, Musthahimah Muhamad, Maywan Hariono (2021) EGFR Inhibitors and Apoptosis Inducers: Design, Docking, Synthesis, and Anticancer Activity of Novel Tri-Chalcone Derivatives Systematic Reviews in Pharmacy., 12,3,809-820
• Sahar Majdi Jaffal, Belal Omar Al-Najjar, Manal Ahmad Abbas (2021) Ononis spinosa alleviated capsaicin-induced mechanical allodynia in a rat model through transient receptor potential vanilloid 1 modulation The Korean Journal of Pain, 34,3,262-270
• Nurul Hanim Salin, Rahmah Noordin, Belal O Al-Najjar, Ezatul Ezleen Kamarulzaman, Muhammad Hafiznur Yunus, Izzati Zahidah Abdul Karim, Nurul Nadieya Mohd Nasim, Iffah Izzati Zakaria, Habibah A Wahab (2020) Identification of potential dual -targets anti- toxoplasma gondii compounds through structure-based virtual screening and in-vitro studies Plos one, 15,5,e0225232
• Sahar M Jaffal, Belal O Al-Najjar, Manal A Abbas, Sawsan A Oran (2020) Identification of potential dual -targets anti- toxoplasma gondii compounds through structure-based virtual screening and in-vitro studies Plos one, 15,5,e0225232
• Manal Ahmad Abbas, Ghaleb Ali Oriquat, Manal Mohamed Abbas, Belal Omar Al-Najjar, Yasser Ibrahim Kandil (2020) Hypolipidaemic and insulin secretagogue activities of (R)-(−)-Carvone The Malaysian Journal of Medical Sciences: MJMS, 27, 6. 39
• Christophorus Fideluno Adhipandito, Diana Putri Kartika Sari Ludji, Eko Aprilianto, Riris Istighfari Jenie, Belal Al-Najjar, Maywan Hariono (2019) Matrix metalloproteinase9 as the protein target in anti-breast cancer drug discovery: an approach by targeting hemopexin domain Future Journal of Pharmaceutical Sciences, 5,1,1
• Maywan Hariono, Rina F Nuwarda, Muhammad Yusuf, Rollando Rollando, Riris I Jenie, Belal Al-Najjar, Jeffry Julianus, Kevin C Putra, Ervan S Nugroho, Yohanes K Wisnumurti, Sangga P Dewa, Benedictus W Jati, Reynaldo Tiara, Ratna D Ramadani, Lailatul Qodria, Habibah A Wahab (2019) Arylamide as potential selective inhibitor for matrix metalloproteinase 9 (MMP9): design, synthesis, biological evaluation, and molecular modeling Journal of chemical information and modeling, 1,60,349-359
• ahar M Jaffal, Manal A Abbas, Mohammad Alsalem, Belal O Al-Najjar (2019) Evidence for the involvement of opioid receptor in Ajuga chamaepitys action in chemical and thermal models of pain in BALB/c mice Medicinal Chemistry Research, 28,7,992-999
• Sahar Majdi Jaffal and Belal Omar Al-Najjar Manal Ahmad Abbas (2019) Analgesic and Anxiolytic Activities of Achillea Biebersteinii: Evidence for the Involvement of GABAergic Systems Oriental Journal of Chemistry, 35,4,1433-1442
• Belal O Al-Najjar, Ashok K Shakya, Fadi G Saqallah, Rana Said (2018) Pharmacophore modeling and 3D-QSAR studies of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors Indian Journal of CHemistry-Section B, 56B, 1200-1206
• Belal O. Al-Najjar (2018) Synthesis, Molecular Docking and Antioxidant Evaluation of Benzylidene Ketone Derivatives Jordan Journal of Biological Sciences , 11, 307-313
• Belal O. Al-Najjar (2018) Investigation of 15-hydroxyprostaglandin dehydrogenase catalytic reaction mechanism by molecular dynamics simulations. Journal of molecular graphics & modelling, 80, 190-196
• Menier Al-Anazi, Belal Al-Najjar, Melati Khairuddean (2018) Structure-Based Drug Design Studies Toward the Discovery of Novel Chalcone Derivatives as Potential Epidermal Growth Factor Receptor (EGFR) Inhibitors Molecules, 23,12,3203
• BO Al-Najjar, AK Shakya, FG Saqallah, R Said (2017) Pharmacophore modeling and 3D-QSAR studies of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors Indian Journal of Chemistry, sectionB, 56B, 1200-1206
• Jafar Mohseni, Belal O Al-Najjar, Habibah A Wahab, Z A M H Zabidi-Hussin and Teguh Haryo Sasongko (2016) Transcript, methylation and molecular docking analyses of the effects of HDAC inhibitors, SAHA and Dacinostat, on SMN2 expression in fibroblasts of SMA patients Journal of Human Genetics, 61, 823-830
• Marzieh YaeghoobiNeni Frimayanti,Chin Fei CheeKusaira K. Ikram, Belal O. Al-Najjar, Sharifuddin M. ZainZanariah Abdullah, Habibah A. Wahab, Noorsaadah Abd. Rahman (2016) QSAR, in silico docking and in vitro evaluation of chalcone derivatives as potential inhibitors for H1N1 virus neuraminidase Medicinal Chemistry Research, 25, 10, 2133–2142
• Ashok K Shakya, Avneet Kaur, Belal O Al-Najjar, Rajashri R Naik (2015) Molecular modeling, synthesis, characterization and pharmacological evaluation of benzo[d]oxazole derivatives as non-steroidal anti-inflammatory agents Saudi Pharmaceutical Journal, In press
• Muchtaridi Muchtaridi, Muhammad Yusuf, Ajeng Diantini, Sy Bing Choi, Belal O. Al-Najjar, Jerry V. Manurung, Anas Subarnas, Tri H. Achmad, Savitri R. Wardhani and Habibah A. Wahab. (2014) Potential Activity of Fevicordin-A from Phaleria macrocarpa (Scheff) Boerl. Seeds as Estrogen Receptor Antagonist Based on Cytotoxicity and Molecular Modelling Studies. International Journal of Molecular Sciences, 15(5):7225-49
• (2013) Molecular Dynamics Simulations Predict the Effect of Rosiglitazone Ionisation on PPARγ Activation 5th CADD 2013, Computer-Aided Drug Design Seminar and Workshop,
• Al-Najjar, B. O., Tengku Muhammad, T. S., Wahab, H. A., Rosli, M. M. & Fun, H.-K (2012) 4-(3-Methylbenzenesulfonamido)phenyl 3-methylbenzenesulfonate Acta Crystallographica Section E, 68, o258
• Al-Najjar, B. O., Tengku Muhammad, T. S., Wahab, H. A., Rosli, M. M. & Fun, H.-K. (2012) 4-(4-Fluorobenzenesulfonamido)phenyl 4-fluorobenzenesulfonate Acta Crystallographica Section E, 68, o1094
• Helal, M. H., Al-Mudaris, Z. A., Al-Douh, M. H., Osman, H., Wahab, H. A., Al-Najjar, B. O., Abdallah, H. H. & Abdul Majid, A. M. S. (2012) Diaminobenzene schiff base, a novel class of DNA minor groove binder International Journal of Oncology, 41, 504-510
• Al-Najjar, B. O., Wahab, H. A., Tengku Muhammad, T. S., Shu-Chien, A. C., Ahmad Noruddin, N. A. & Taha, M. O. (2011) Discovery of new nanomolar peroxisome proliferator-activated receptor γ activators via elaborate ligand-based modeling European Journal of Medicinal Chemistry, 46, 2513-2529
• Tran, L., Choi, S. B., Al-Najjar, B. O., Yusuf, M., Wahab, H. A. & Le, L (2011) Discovery of Potential M2 Channel Inhibitors Based on the Amantadine Scaffold via Virtual Screening and Pharmacophore Modeling Molecules, 16, 10227-10255
• Habibah A.Wahab, Nornisah Mohamed, Rashidah A.Rahim, and Belal Omar Alnajjar (2006) Natural Flavonoids for the treatment of hyperurecemia, Molecular docking and crystallography studies. FMBE Proceedings , 14, pp 178-182

Published Books:

• First-Pass Metabolism Considerations in Pharmaceutical Product Development (2018) Dosage Form Design Considerations Academic Press
• (2018) First-Pass Metabolism Considerations in Pharmaceutical Product Development Academic Press