Particle Size Non-invasive back scatter (NIBSR) technology takes particle sizing to new levels of sensitivity in the 0.6nm to 6 micron range. The new Zetasizer Nano ZS is the choice for accurate, reliable and repeatable size analysis including protein melting point determination. Proteins and polymer analysis; Little or no dilution necessary; Pharmaceuticals; Nanoparticles; Optoelectronics; Zeta Potential The new Zetasizer Nano ZS offers the highest ever sensitivity, accuracy and resolution of zeta potential. This is achieved by a combination of laser Doppler velocimetry and phase analysis light scattering (PALS) in Malvern Panalytical's patented M3-PALS technique. Even samples of very low mobility can be analyzed and their mobility distributions calculated. Emulsion stability; Formulation stability ; Water treatment; Pigment performance; Impurity determination Molecular Weight Using static light scattering (SLS) and the classical Debye plot, the molecular weight of random coiled polymers up to 5 x 105 Da as well as globular polymers and proteins up to 2 x 107 Da can be determined without the necessity for multi-angle measurement. Protein and polymer characteristics; Protein crystal screening ; 2nd virial coefficient determination Micelle structure; Protein-ligand binding.