Targeted analysis of Drugs /metabolites in plasma/serum/tissue homogenate/carcinogen/intermediate in API/pesticides/degraded drugs/ pharmaceuticals/steroids/flavors and several compounds in Pharmaceuticals/ markers/ biochemicals in blood/ expired air/ Plasma/Serum/tissue homogenate/CSF and saliva using sophisticated sample collection and preparation techniques. Studies of matrix effect. Small sample volume 3.0 microliter. Development, Validation and Risk assessment of Method as per ICH guidelines using DoE (ICH Q14: Analytical Procedure Development and Revision of Q2(R1) Analytical Validation dated 14 November 2018) and draft ICH guideline M10 (2019). Preclinical studies of chemical compounds, pharmacokinetics and toxicokinetics studies of drugs/ NCE/ and NDAs.