FORMULATION AND PK DRUG DELIVERY

Overview

The PDRC has an experienced formulation, drug metabolism, pharmacokinetics and drug delivery team with efficient research professionals and sophisticated recent instruments.


Research direction

This team plays main role in the formulation development, drug discovery process and works side by side with other groups. The team has sound record on the development and validation of various bio-analytical methods for bioavailability (BA) and DMPK studies of NCE, small molecules, and peptides. The team expertise in UFLC-PDA-FLD, UFLC-UV, hyphenated technologies like LC-MS-MS-4500-QTRAP and GC-MS and has successfully applied these methods for the analysis of drugs in serum, plasma, saliva, body fluids and tissue. The team has developed and utilized several different polymers, carrier linked drugs, nano-carriers, nano-emulsions, and liposomal carrier for the successful delivery of potent molecule to the different targets including TNBCs. We also have expertise in thermo sensitive gels, conventional and sustain released formulation. Some Members of the team have participated as investigator or co-investigator in different phase of preclinical and clinical trial (Phase I – phase III) earlier. We assist in the development of small molecule, peptide and predicts their fate (ADME). The team also evaluates the drug-excipients compatibity, drug-drug interaction, drug toxicity (acute and chronic as well as toxicokinetics studies), stability, drug-affinity and efficacy of drug. GLP and GCP facilities are supported by a dedicated Quality Assurance (QA) Team. Last but not least, we also provide support for identification and characterization of unknown molecules.

 

Techniques

The PDRC Formulation, Drug Metabolism, Pharmacokinetics and Drug Delivery include following facilities:
LC-MS-MS-4500-QTRAP, GC-MS, UPLC-PDA, UPLC-UV, GC-FID, Biotage-Alstra Peptide and Small Molecule Synthesizer, Mini-Liposome Factory, Malvern Nanosizer ES90, Hanson Automated Diffusion Cell equipment, Lyophilizer, Class-II Biosafety Cabinates, UV-Visible spectrophotometer, IR spectrophotometer.

Prof. Dr. Ashok Shakia
Group Leader


Dr. Rana Saed
Academic staff


Dr. Farezeh Muhana
Academic staff


Dr. Wesam Ammari
Academic staff


Dr. Naeem Shaalan
Academic staff


Dr. Israa Al-AlAni
Academic staff


Lecturer Enas Daoud
Academic staff


Lecturer Randa Atwan
Academic staff


Mr. Rahmeh Hafez
Lab Staff


Mrs. Islam Frehat
Lab Staff


Mrs. Dina Abu-AlSamen
Lab Staff


Mrs. Razan Madi
Lab Staff


Mrs. Ayat Alzoubi
Lab Staff

Contact Group on

ak_shakya@ammanu.edu.jo

Contact Center On

  • Email: pdrc@ammanu.edu.jo
  • Phone: +962 5 3500211
  • Extension: 2346
  • Address: Al-Ahliyya Amman University / Amman-Jordan- Al Salt Road / Zip-Code (Postal Address): (19328)
  • Fax: +962 6 5335169

Al-Ahliyya Amman University

Email: Public@ammanu.edu.jo

 

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